Kronos Advanced Technologies Inc. (OTCMKTS:KNOS) Stock Surges 150% in July: What’s Next?
One of the more interesting companies to have emerged in recent years is that of Kronos Advanced Technologies Inc. (OTCMKTS:KNOS) and in recent times the company has made some notable moves. The company is involved in the product development and production space and is primarily known for having revolutionised the way in which air is moved, filtered and sterilized.
Major Triggers
Earlier this month, the company announced the launch of the 1-800-SAFE AIR Independent Sales Rep program, by way of which the company intends to sign up as many as 200 sales representatives across the United States in the third fiscal quarter.
The move from Kronos is aimed at selling a larger volume of its products through a new sales channel altogether. Kronos went for the program in response to feedback from both customers and shareholders. Kronos is going to supply the sales representatives with marketing materials, online marketing support, and also marketing videos.
In addition to that, the sales representatives will also get incentives which include promotional items and special pricing. At this point in time, the company is considering several online portals for the purpose of recruiting new independent sales representatives.
While the launch of this program could prove to be a long term positive, there was another important announcement from the company this month. Kronos announced last week that it has decided to transform the company into a Public Benefit Corporation. This implies that the well being of the consumers is the primary concern of the company rather than profitability.
The Chief Transformation Officer of Kronos Advanced stated that the company wishes to become one of the few publicly traded firms which put the interests of the customers above profit. It is a major move for the company and it remains to be seen how it is going to have an effect on its operations in the months to come.
Aptevo Therapeutics Inc (NASDAQ:APVO) Gains Momentum On a Positive News
One of the stocks that gathered momentum on Tuesday was that of the biotech firm Aptevo Therapeutics Inc (NASDAQ:APVO). It came about primarily due to the emergence of positive news regarding the company’s business. The company revealed that it has engaged the services of Piper Sandler in order to sell the royalty payment streams and milestone payouts for two of its products.
Engages Piper Sandler to Sell its RUXIENCE and IXINITY(R) Royalty Streams & Milestones
The products in question are IXINITY and RUXIENCE. The company had announced last month that its royalty payments for RUXIENCE from pharmaceutical giant Pfizer is going to be in single digits and will take into consideration the net sales of the product in the European Union, Japan, and United States. The royalty term is for 7 years.
On the other hand, the royalty payments for IXINITY are going to be paid by Medexus Pharmaceuticals and will take into consideration the net sales of the product in Canada and the United States. The royalty term is going to run until 2035 and payments are going to be made on a quarterly basis.
Aptevo could also be entitled to a milestone payment of $11 million. Royalty payments can be a highly lucrative source of income for companies like Aptevo and there has been a buzz around the company ever since the company made the announcement regarding the royalty payments back on June 25.
The Chief Executive Officer of the company Marvin L. White stated that the royalties will provide Aptevo with much needed non-dilutive cash so that it can work on its other products. He went on to state that the decision to sell the royalties and milestones to Piper Sandler is consistent with Aptevo’s quest to further strengthen its financial position.
At the end of the day, it takes a lot of money to fund the research and development of new medicines and the latest move from Aptevo has naturally excited the market.
Ibio Inc (NYSEAMERICAN:IBIO) Contonies to Hot New Highs On Coronavirus Pandemic
Over the course of the past few months, many biotech companies have seen their stocks soar on the back of their efforts to create medicines or vaccines for the coronavirus pandemic. One such stock if Ibio Inc (NYSEAMERICAN:IBIO), which has gained as much as 490% so far as it pushes to bring a COVID 19 vaccine to the market.
What to Expect Now?
The secret sauce for iBio is its proprietary technology called Fast Pharming that allows it to produce vaccines in bulk and hence, gives it a competitive edge over its peers. That has attracted some institutional investors to the company but ultimately its weak balance sheet remains a matter of concern.
However, it could be worthwhile to take a closer look at Fast Pharming for anyone who is interested in iBio. The technology streamlines the production process considerably and leads to greater efficiency. Moreover, it also makes iBio an attractive proposition for those companies which are developing a COVID 19 vaccine but do not yet have the capability of scaling up production considerably.
At this point in time, the company is collaborating with Beijing CC Pharming, Infectious Disease Research Institute. That being said, it should be borne in mind that iBio has not managed to win a contract yet.
At this point, the company has one of the lowest market caps in the biotech sector, and on top of that its free cash flow, as well as margins, have been in the negative territory. Hence, the iBio stock has managed to do much better than its fundamentals suggest. However, the research and development investment has to be ramped up by iBio if it wishes to be a major player in the sector. Now that many companies are working on COVID 19 vaccines, iBio has emerged as a potential winner due to its Fast Pharming technology. It can churn our as much as 500 million doses of the vaccine a year and that is a significant figure. Investors could do well to keep an eye on the developments.
Five Prime Therapeutics (NASDAQ: FPRX) Hits New High on Analyst’s Optimism
American Bio Medica Corporation (OTCMKTS:ABMC) Surges 550% in a Month on Covid-19 Buzz
Evoke Pharma Inc (NASDAQ:EVOK) Hits New High After the FDA Approval
Digital Locations Inc (OTCMKTS:DLOC) Stock Skyrockets As it Joins Experimental 5G Wireless Network
Can You Name the $15 Million Stock with Eyes on a $35 Billion Market
Long-term success on Wall Street is all about getting ahead of the story everyone else will be chasing months or even weeks down the road. That’s why Endra Life Sciences Inc. (NASDAQ-NDRA) has my attention now.
Look at NDRA today and it’s more potential than powerhouse. The company doesn’t even make room for revenue on its quarterly pre-revenue reports yet. It hasn’t sold anything. The profitability that institutional investors demand is probably years away.
On paper, all it has to back up its $15 million market cap is $3 million in cash, miscellaneous other assets and a whole lot of talent and ideas. Big ideas. Many patents were collected over the last five years, 5 others overseas and dozens of others around the world.
Those ideas and the talent to turn them into commercial reality are the important thing about NDRA right now. All in all, they’re why the analysts who know this little company best say it will be worth $5.00 to $6.00 under the right conditions.
The firm with the most bearish take on NDRA just raised its target to $2.75 and left the door open to additional upgrades beyond. That’s pretty big talk for a stock that was trading at $0.65 at the time . . . and even now, after a blockbuster 65% run, remains within sight of a lowly $1.
THE BILLION-DOLLAR OPPORTUNITY
What have the analysts figured out that the market can’t see? Putting the dots together starts with four simple letters: N A S H.
It stands for Non-Alcoholic Steato Hepatitis. It means fat builds up in the liver (steatosis) and starts causing inflammation. In effect, it’s a form of self-inflicted hepatitis. In extreme cases, scarring and cirrhosis follow. It resembles alcoholic liver disease, only without the liquor.
And it’s a silent health epidemic that we know affects 20 million Americans and probably up to 80 million more people carry the fatty markers without knowing. Do the math and it kills more people than coronavirus . . . but because it’s progressive, the longer you have it, the worse your odds get.
NASH is now the top reason people need liver transplants today. Bigger than hepatitis. It can even cause cancer. While there’s no cure right now, Big Pharma has already spent BILLIONS ($1 billion from Gilead alone, and even then, that drug failed) trying to ring that bell. There are literally dozens of hopeful drugs in the clinic now. Most will fizzle out on the road but those that finally make it all the way to FDA approval will share a $35 billion sales jackpot.
Is it any wonder Wall Street goes nuts on the faintest whiff of progress toward a NASH cure? But if you’re curious about where tiny little NDRA fits into the story and how it hopes to compete with just about every ambitious drug company around, stop wondering.
NDRA isn’t racing the giants to a cure. That’s a fool’s game. Instead, management did a little reading between the lines and realized that they can help by coming up with better ways to detect NASH in its early stages.
Detection is essential. And it’s difficult. “Early detection is one of the biggest challenges” because by the time you notice the symptoms, you’re really sick.
Right now there are really only two ways to test for NASH: 1) a liver biopsy and 2) a full MRI to peek inside the body. The biopsy is invasive and uncomfortable. The MRI is expensive and relies on increasingly irreplaceable helium to run the magnets.
Between Option A and Option B, there’s no easy way to screen for who has NASH and who doesn’t. When you’re looking at a silent and lethal epidemic, it’s a good idea to run as many tests as you can . . . tens of millions just to identify all the people who have the condition now.
So NDRA came up with Option C. and differentiate fat from lean tissues.
THE NDRA ALTERNATIVE
Because fat is the problem, recognizing it on the scanner is all it takes. You’ve got NASH or you don’t. Follow-up tests can gauge progress or remission once those new drugs hit the market, telling doctors when to prescribe a pill or how to evaluate its effects.
NDRA’s system is proprietary. Only their machines know how to decode the waves and find the fat. The procedure doesn’t require gigantic magnets or rare helium. The machine costs 1/50 of an MRI suite.
And hospitals don’t have to buy an all-new imaging suite to run the test. This system TAEUS sits next to the existing ultrasound and plugs right in.
Say there are 20,000 radiology labs in the developed world that do ultrasound screens now. NDRA can ultimately gross $1 billion selling them each a $50,000 TAEUS unit. That’s not a bad windfall at all for a company that’s currently valued at $15 million, right? For little NDRA to trade at even 1X that “base addressable market” opportunity, it would need to unlock truly massive upside . . . which would in turn give shareholders who got in early plenty to cheer.
From there, the accounting really adds up. The system can also map temperature in the body to help guide laser- and heat-based surgical procedures. It can track blood flow down to the microscopic level. Ultimately TAEUS has the potential to spot blockages to diagnose and assist treatment of a wide range of conditions. And throughout, NDRA has made sure to keep building in ways to sell disposable equipment and charge licensing fees to people who have already built the machine.
Remember, tens of millions of people in America alone (not even counting the rest of the world) probably have NASH and need to get a definitive diagnosis. Biopsies cost $1,500 apiece. An MRI scan is running close to double that . . . and that’s when the machines are actually working and slots are available! Even if the disposables only cost a few dollars per procedure, we’re looking at real money here.
All in all, management suspects there’s $18 billion to chase. At that point, the multiplier gets vast. Again, NASH is a big problem and big money: here’s a report suggesting that just selling the genetic markers that say you MIGHT get the disease is going to be worth $2 billion a year very soon. People with the markers will still need physical confirmation. That’s where NDRA comes in.
SOLVING THE BILLION-DOLLAR PUZZLE
Of course it’s a long way from a $15 million stock with big dreams to the kind of company that can realistically conquer billion-dollar markets. NDRA today reflects reality on the ground today. However, management has done a lot of work paving the road from here to there.
To start, nothing ever happens in healthcare without regulatory approval. NDRA has already gotten clearance in Europe and is now looking to file its 510(k) medical device submission this summer, so the clock is ticking there. If you aren’t familiar with the 510(k) process, it’s a lot faster than what it takes to get a drug approved.
You really just need to prove safety and effectiveness. As long as your system doesn’t hurt people and actually provides the medical benefit you claim it does, the FDA tends to give you the green light to start selling. Historically it takes less than six months, so as long as NDRA makes its 2Q timeline, we can hope to hear back by the end of the year.
But maybe NDRA wants to wait and make sure the application is as strong as possible. A few months ago their research revealed a past FDA decision that might raise the odds of approval as long as they “do it that way.” Getting the data points in line has taken a little more time.
Meanwhile, the Europeans have already signed off on the device. That’s 5,500 hospitals or a $275 million revenue opportunity ($50,000 per TAEUS) that just opened up. Even if nothing happens on other regulatory fronts for months to come, NDRA is now free to start making money. And at this point, any slice of the initial $275 million market will feel mighty good.
Once you get the green light, you still need to convince the doctors they need to lobby hospitals to buy the equipment. NDRA has teamed up with the liver experts at the Medical College of Wisconsin while partnerships with the University of Pittsburgh Medical Center and Rocky Vista University do their share to spread the word. The more data that gets out into the journals, the easier the job gets.
A lot of doctors are probably eager for an efficient NASH testing system, so resistance is probably going to be mild at worst. When potential customers actively want to buy what you’re selling, all you have to do is give them a way to hand you the money.
And that’s the last big piece of the puzzle snapping into place. NDRA isn’t building a vast sales force to approach thousands of hospitals. That takes time and a whole lot of money. Instead, they’ve teamed up with GE Healthcare . . . which sells and supports the ultrasound machines that TAEUS plugs into.
If the ultrasound is the razor and TAEUS is the fancy new blade, NDRA has made a very powerful friend. GE is happy because the added functionality makes the ultrasound more relevant. NDRA gets to virtually “ride along” on the sales conversations. That’s what “facilitating introductions” means in that last link. Do you have an ultrasound machine? Did you buy it from GE? Have you heard that NDRA can leverage your existing machine to detect NASH?
THE BOTTOM LINE
Add it all up, NDRA has a solid shot at getting a lot of those hospitals to upgrade their existing ultrasound machines. Once they all do it, that’s billion-dollar potential, a real company maker.
Look at a company like Exact Sciences, which makes mail-in colon cancer tests. It took the last two years to book $1.3 billion in sales. This year it might do $1.2 billion as well. That once-obscure company is now worth close to $13 billion.
According to that math, NDRA only needs to sell a couple dozen TAEUS systems a year to justify its current market cap. The European hospitals can buy now. Even if NDRA hits 1% penetration of that market, we’re looking at a lot more than “a couple dozen” sales.
Remember, GE is helping. The data is flowing. Awareness around NASH isn’t fading. Doctors are waking up to the depth of the problem they’re facing as liver cancer and transplant numbers hit the red zone.
Day by day, those hospitals will get more receptive. And then “a couple dozen” will look small, at which point NDRA translates its potential into something a lot more substantial . . . and shareholders who saw the future in an obscure $15 million stock will be able to brag that they were early and right.
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